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Synthesis of α‐Hydroxy Carboxylic Acids via a Nickel(II)‐ Catalyzed Hydrogen Transfer Process
Author(s) -
Tang Guo,
Cheng ChienHong
Publication year - 2011
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201100241
Subject(s) - chemistry , catalysis , tetrahydrate , hydrogen , nickel , lactic acid , carboxylic acid , primary (astronomy) , base (topology) , acceptor , organic chemistry , alkylation , transfer hydrogenation , combinatorial chemistry , medicinal chemistry , ruthenium , bacteria , mathematical analysis , physics , mathematics , astronomy , biology , crystal structure , genetics , condensed matter physics
A new catalytic system for β‐alkylation of lactic acid with primary alcohols has been developed. In the presence of nickel(II) acetate tetrahydrate [Ni(OAc) 2 (H 2 O) 4 ] and base, lactic acid reacts with primary alcohols to afford the corresponding coupled α‐hydroxy carboxylic acids in good to excellent yields via a hydrogen transfer process without any hydrogen acceptor or hydrogen donor.