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Synthesis of Diarylalkynes by Iron/Copper Co‐Catalyzed Decarboxylative sp sp 2 Coupling of Alkynyl Carboxylic Acids and Aryl Halides
Author(s) -
Li Tingyi,
Qu Xiaoming,
Zhu Yan,
Sun Peng,
Yang Hailong,
Shan Yuqin,
Zhang Hongxin,
Liu Defu,
Zhang Xiang,
Mao Jincheng
Publication year - 2011
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201100238
Subject(s) - chemistry , halide , aryl , catalysis , decarboxylation , copper , iodide , ligand (biochemistry) , palladium , coupling (piping) , medicinal chemistry , organic chemistry , alkyl , biochemistry , receptor , mechanical engineering , engineering
The highly effective decarboxylative sp ‐ sp 2 coupling of alkynylcarboxylic acids with various aryl halides was carried in the presence of low‐cost and readily available copper(I) iodide/iron(III) acetylacetonate under ligand‐free and palladium‐free conditions using low catalyst loadings. This protocol makes such coupling reactions more practical and useful.