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Grignard‐Type Arylation of Aldehydes via a Rhodium‐Catalyzed CH Activation under Mild Conditions
Author(s) -
Yang Luo,
Correia Camille A.,
Li ChaoJun
Publication year - 2011
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201100232
Subject(s) - chemistry , rhodium , aryl , catalysis , grignard reaction , medicinal chemistry , reaction conditions , combinatorial chemistry , organic chemistry , functional group , alkyl , reagent , polymer
An efficient Grignard‐type arylation of aldehydes via aryl CH activation was achieved under mild conditions catalyzed by rhodium. The reaction provides an easy access to a wide variety of benzyl alcohols and can tolerate various functional groups as well as air and water.