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N‐Heterocyclic Carbene‐Catalyzed Cyclization of Unsaturated Acyl Chlorides and Ketones
Author(s) -
Shen LiTao,
Shao PanLin,
Ye Song
Publication year - 2011
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201100178
Subject(s) - chemistry , carbene , trifluoromethyl , oxindole , isatin , catalysis , medicinal chemistry , organic chemistry , combinatorial chemistry , alkyl
A straightforward synthesis of optically active trifluoromethyl dihydropyranones and spirocyclic oxindole‐dihydropyranones has been realized by the chiral N‐heterocyclic carbenes‐catalyzed cyclization of α,β‐unsaturated β‐methylacyl chlorides with activated trifluoromethyl ketones or isatin derivatives.