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Novel Cyclization Reactions of Aminoallenes
Author(s) -
Alcaide Benito,
Almendros Pedro
Publication year - 2011
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201100160
Subject(s) - chemistry , electrophile , stereoselectivity , moiety , catalysis , combinatorial chemistry , block (permutation group theory) , component (thermodynamics) , stereochemistry , organic chemistry , physics , geometry , mathematics , thermodynamics
The aminoallene moiety represents an excellent building block for heterocyclization reactions, affording a large number of cyclic structures containing different sized skeletons in a single step. This strategy has been studied under basic and electrophile‐induced conditions. More recently, the use of transition metal catalysis has been introduced as an alternative relying on the activation of the allenic component. This overview focuses on the most recently developed cyclizations of aminoallenes along with remarkable early works accounting for the mechanism, as well as for the regio‐ and stereoselectivity of the cyclizations.