Premium
Diastereoselective and Highly Enantioselective Henry Reactions using C 1 ‐Symmetrical Copper(II) Complexes
Author(s) -
Chougnet Antoinette,
Zhang Guoqi,
Liu Kegang,
Häussinger Daniel,
Kägi Andreas,
Allmendinger Thomas,
Woggon WolfD.
Publication year - 2011
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201100157
Subject(s) - chemistry , enantioselective synthesis , copper , nitro , nitroaldol reaction , catalysis , medicinal chemistry , stereochemistry , organic chemistry , alkyl
Catalytic Henry reactions of aliphatic aldehydes and prochiral nitro compounds were investigated using copper(II) complexes of 14 C 1 ‐symmetrical ligands derived from (1 R ,2 R )(−)‐diaminocyclohexane. β‐Nitro alcohols with syn : anti ratios of up to 5.7 and excellent ee values for both diastereosimers were obtained.