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Diastereo‐ and Enantioselective Direct Aldol Reactions in Aqueous Medium: A New Highly Efficient Proline‐Sugar Chimeric Catalyst
Author(s) -
Pedatella Silvana,
De Nisco Mauro,
Mastroianni Domenico,
Naviglio Daniele,
Nucci Ada,
Caputo Romualdo
Publication year - 2011
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201100143
Subject(s) - chemistry , aldol reaction , cyclohexanone , enantioselective synthesis , catalysis , proline , aqueous medium , enantiomer , organic chemistry , aqueous solution , sugar , combinatorial chemistry , biochemistry , amino acid
A new synthetic catalyst, capable of acting like an enzyme in the accomplishment of direct aldol reactions, is presented. Excellent results, in terms of chemical yields and diastereo‐/enantiomeric ratios, are reported for the catalyzed additions of cyclohexanone to variously substituted benzaldehydes.