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Mechanistic Switch via Subtle Ligand Modulation: Palladium‐Catalyzed Synthesis of α,β‐Substituted Styrenes via CH Bond Functionalization
Author(s) -
FloresGaspar Areli,
Martin Ruben
Publication year - 2011
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201100140
Subject(s) - chemistry , surface modification , palladium , ligand (biochemistry) , stereoselectivity , catalysis , combinatorial chemistry , stereochemistry , organic chemistry , receptor , biochemistry
A new catalyst system able to efficiently perform the synthesis of styrenes via CH bond functionalization and a subtle ligand modification are described. The high level of activity achieved allows for the synthesis of highly functionalized α,β‐substituted styrenes, even the elusive E ‐configured trisubstituted olefins, in a regio‐ and stereoselective manner. Mechanistic experiments allowed for the identification of the corresponding synthetic intermediates.