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Chemoenzymatic One‐Pot Synthesis of γ‐Butyrolactones
Author(s) -
Korpak Margarete,
Pietruszka Jörg
Publication year - 2011
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201100110
Subject(s) - chemistry , alcohol dehydrogenase , alcohol , enzyme , reduction (mathematics) , cascade , stereochemistry , organic chemistry , chromatography , geometry , mathematics
The synthesis of enantio‐ and diastereomerically pure γ‐butyrolactones is described using a one‐pot, two‐enzyme cascade. Ethyl 2‐methyl‐4‐oxopent‐2‐enoate ( 2 ) was reduced selectively first in a 1,4‐reduction using the old yellow enzyme (OYE1) [EC 1.6.99.1] and consecutively in a 1,2‐reduction by an alcohol dehydrogenase [EC 1.1.1.2].