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Palladium‐Catalyzed Highly Chemo‐, Regio‐ and Stereoselective Synthesis of Eight‐ to Ten‐Membered Lactones from Allenyl 3‐Oxoalkanoates and Organic Halides
Author(s) -
Wan Baoqiang,
Jia Guochen,
Ma Shengming
Publication year - 2011
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201100075
Subject(s) - stereoselectivity , chemistry , palladium , halide , allylic rearrangement , catalysis , organic synthesis , organic chemistry , medicinal chemistry
A highly chemo‐, regio‐, and stereoselective synthesis of eight‐ to ten‐membered lactones via the coupling cyclization of readily available allenyl 3‐oxoalkanoates and organic halides through an anti ‐π‐allylic palladium intermediate is reported. The yields ranged from moderate to good.