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Synthesis of 4‐Aryl‐2(5 H )‐furanones by Gold(I)‐Catalyzed Intramolecular Annulation
Author(s) -
Sun Haifeng,
Huang He,
Zhang Dengyou,
Feng Enguang,
Qian Wangke,
Zhang Lei,
Chen Kaixian,
Liu Hong
Publication year - 2011
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201100069
Subject(s) - annulation , chemistry , intramolecular force , aryl , triphenylphosphine , catalysis , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry , alkyl
A novel method that involves intramolecular annulation and a new type of rearrangement has been developed for the synthesis of 4‐aryl‐2(5 H )‐furanones. A variety of prop‐2‐ynyl 3‐oxo‐3‐phenylpropanoates undergo annulation cyclization in the presence of chloro(triphenylphosphine)gold and trifluoromethanesulfonic to afford the desired products in moderate to high yields.