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Tandem Catalysis by Lipase in a Vinyl Acetate‐Mediated Cross‐Aldol Reaction
Author(s) -
Kumar Manjeet,
Shah Bhahwal A.,
Taneja Subhash C.
Publication year - 2011
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201000980
Subject(s) - chemistry , aldol reaction , lipase , acetone , vinyl acetate , acetaldehyde , tandem , catalysis , organic chemistry , cascade reaction , aldol condensation , enol , enzyme , ethanol , polymer , materials science , copolymer , composite material
The lipase Novozym435 (0.6% w/w) was used in tandem with organocatalysts in a first vinyl/isopropenyl acetate‐mediated aldol reaction. The reaction was facilitated through the lipase‐catalyzed in situ generation of acetaldehyde/acetone. The important features of the present methodology include the mild and facile reaction conditions, regenerability of the lipase, comparatively high yields and minimal side product formation.