Premium
Recent Advances in Palladium‐Catalyzed Cascade Cyclizations
Author(s) -
Vlaar Tjøstil,
Ruijter Eelco,
Orru Romano V. A.
Publication year - 2011
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201000979
Subject(s) - palladium , chemistry , cascade , organic synthesis , catalysis , coupling reaction , nanotechnology , combinatorial chemistry , reactivity (psychology) , organic chemistry , materials science , medicine , alternative medicine , pathology , chromatography
The importance of palladium‐catalyzed cross coupling reactions in contemporary organic synthesis is undisputed and underlined by the Nobel Prize for Chemistry in 2010. In addition to the highly efficient cross coupling reactions for single CC bond construction, palladium‐catalyzed cascade processes involving multiple bond formations have emerged in recent years as valuable tools for the rapid synthesis of complex molecular scaffolds. This review presents an overview of the most relevant developments in this field, with a focus on the generation of diverse poly‐ and heterocyclic scaffolds. The generally well understood reactivity of palladium has allowed the discovery of many intriguing novel cascade processes, and the creativity of the synthetic community will undoubtedly lead to many more discoveries in the future.