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Chlorinative Cyclization of 1,6‐Enynes by Enantioselective Palladium(II)/Palladium(IV) Catalysis
Author(s) -
Takenaka Kazuhiro,
Hashimoto Shintaro,
Takizawa Shinobu,
Sasai Hiroaki
Publication year - 2011
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201000926
Subject(s) - palladium , chemistry , enantioselective synthesis , catalysis , intramolecular force , ligand (biochemistry) , combinatorial chemistry , catalytic cycle , medicinal chemistry , organic chemistry , stereochemistry , receptor , biochemistry
A novel asymmetric catalysis via a palladium(II)/palladium(IV) cycle has been developed by utilizing a chiral spiro bis(isoxazoline) ligand (SPRIX). Intramolecular chlorinative cyclization of 1,6‐enynes catalyzed by a palladium‐SPRIX complex proceeded enantioselectively to afford α‐methylene‐γ‐lactone derivatives.