Chlorinative Cyclization of 1,6‐Enynes by Enantioselective Palladium(II)/Palladium(IV) Catalysis | Zendy

Takenaka Kazuhiro | Zendy; Hashimoto Shintaro | Zendy; Takizawa Shinobu | Zendy; Sasai Hiroaki | Zendy

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Chlorinative Cyclization of 1,6‐Enynes by Enantioselective Palladium(II)/Palladium(IV) Catalysis

Author(s) -

Takenaka Kazuhiro,

Hashimoto Shintaro,

Takizawa Shinobu,

Sasai Hiroaki

Publication year - 2011

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201000926

Subject(s) - palladium , chemistry , enantioselective synthesis , catalysis , intramolecular force , ligand (biochemistry) , combinatorial chemistry , catalytic cycle , medicinal chemistry , organic chemistry , stereochemistry , receptor , biochemistry

A novel asymmetric catalysis via a palladium(II)/palladium(IV) cycle has been developed by utilizing a chiral spiro bis(isoxazoline) ligand (SPRIX). Intramolecular chlorinative cyclization of 1,6‐enynes catalyzed by a palladium‐SPRIX complex proceeded enantioselectively to afford α‐methylene‐γ‐lactone derivatives.

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