Gold‐Catalyzed Direct Intermolecular Coupling of Ketones, Secondary Amines, and Alkynes: A Facile and Versatile Access to Propargylic Amines Containing a Quaternary Carbon Center | Zendy

Cheng Ming | Zendy; Zhang Qiang | Zendy; Hu XiaoYu | Zendy; Li BoGang | Zendy; Ji JianXin | Zendy; Chan Albert S. C. | Zendy

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Gold‐Catalyzed Direct Intermolecular Coupling of Ketones, Secondary Amines, and Alkynes: A Facile and Versatile Access to Propargylic Amines Containing a Quaternary Carbon Center

Author(s) -

Cheng Ming,

Zhang Qiang,

Hu XiaoYu,

Li BoGang,

Ji JianXin,

Chan Albert S. C.

Publication year - 2011

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201000914

Subject(s) - chemistry , quaternary carbon , intermolecular force , catalysis , primary (astronomy) , carbon fibers , solvent , coupling (piping) , combinatorial chemistry , organic chemistry , molecule , enantioselective synthesis , mechanical engineering , physics , materials science , astronomy , composite number , engineering , composite material

The first gold‐catalyzed direct intermolecular coupling of ketones, secondary amines, and alkynes was achieved under mild and solvent‐free conditions. The present methodology provides a promising and versatile tool for the construction of propargylic amines with a newly‐formed quaternary carbon center.

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