Premium
Gold‐Catalyzed Direct Intermolecular Coupling of Ketones, Secondary Amines, and Alkynes: A Facile and Versatile Access to Propargylic Amines Containing a Quaternary Carbon Center
Author(s) -
Cheng Ming,
Zhang Qiang,
Hu XiaoYu,
Li BoGang,
Ji JianXin,
Chan Albert S. C.
Publication year - 2011
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201000914
Subject(s) - chemistry , quaternary carbon , intermolecular force , catalysis , primary (astronomy) , carbon fibers , solvent , coupling (piping) , combinatorial chemistry , organic chemistry , molecule , enantioselective synthesis , mechanical engineering , physics , materials science , astronomy , composite number , engineering , composite material
The first gold‐catalyzed direct intermolecular coupling of ketones, secondary amines, and alkynes was achieved under mild and solvent‐free conditions. The present methodology provides a promising and versatile tool for the construction of propargylic amines with a newly‐formed quaternary carbon center.