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Efficient Iron‐Catalyzed Direct β‐Alkylation of Secondary Alcohols with Primary Alcohols
Author(s) -
Yang Jian,
Liu Xin,
Meng DaLi,
Chen HongYan,
Zong ZhiHui,
Feng TingTing,
Sun Kai
Publication year - 2012
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201000907
Subject(s) - chemistry , alkylation , catalysis , primary (astronomy) , hydrogen , noble metal , organic chemistry , base (topology) , combinatorial chemistry , mathematical analysis , physics , mathematics , astronomy
The efficient iron‐catalyzed direct β‐alkylation of secondary alcohols with primary alcohols is described. In the presence of the commercially available iron catalyst (ferrocenecarboxaldehyde, 1b ) and a catalytic amount of base, the reactions give β‐alkylated higher alcohols in high yields in the absence of any sacrificial agents (hydrogen acceptors or hydrogen donors) and nitrogen or phosphorus ligands. For the first time, iron is employed as an inexpensive and environmentally benign alternative with high atom efficiency to noble metal‐based catalysts in this type of reaction.