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Tandem Catalysis: Alcohol Oxidation and CC Bond Formation via CH Bond Activation
Author(s) -
Simon MarcOlivier,
Ung Gaël,
Darses Sylvain
Publication year - 2011
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201000884
Subject(s) - chemistry , tandem , catalysis , alcohol , ruthenium , atom economy , alcohol oxidation , combinatorial chemistry , functional group , cascade reaction , organic chemistry , medicinal chemistry , materials science , polymer , composite material
A tandem process involving oxidation of a benzylic alcohol functionality followed by hydroarylation is described. These two atom‐economic sequences are very convenient to access functionalized aromatic ketones, using simple ruthenium trichloride as catalyst precursor. Moreover they appear to be highly compatible, tolerant, and selective toward various functional groups, and the ease of the protocol should make it very convenient for synthetic purposes.