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Copper‐Catalyzed Aromatic Trifluoromethylation via Group Transfer from Fluoral Derivatives
Author(s) -
Kondo Hideaki,
Oishi Masahiro,
Fujikawa Kenichi,
Amii Hideki
Publication year - 2011
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201000825
Subject(s) - trifluoromethylation , chemistry , hemiaminal , catalysis , aryl , iodide , copper , organic chemistry , combinatorial chemistry , trifluoromethyl , alkyl
Starting from a readily available fluoral derivative, catalytic aromatic trifluoromethylation has been successfully achieved. A small amount of copper(I) iodide‐phenanthroline complex catalyzed the cross‐coupling reactions of aryl/heteroaryl iodides with the O ‐silylated hemiaminal of fluoral (trifluoroacetaldehyde) to provide trifluoromethylated arenes in moderate to high yields.