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Cyanides‐Free Cyanation of Aryl Halides using Formamide
Author(s) -
Sawant Dinesh N.,
Wagh Yogesh S.,
Tambade Pawan J.,
Bhatte Kushal D.,
Bhanage Bhalchandra M.
Publication year - 2011
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201000807
Subject(s) - cyanation , xantphos , formamide , chemistry , aryl , cyanide , halide , palladium , solvent , catalysis , organic chemistry , alkyl
A novel method for cyanation of aryl halides using formamide as a non‐toxic cyanide source is reported. It is a single‐step, solvent‐free method wherein formamide itself acts as solvent as well as source of cyanide in the presence of phosphorus oxychloride and palladium acetate/xantphos catalyst. Aryl iodides as well as aryl bromides provided moderate to excellent yields of up to 93%.
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