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Palladium‐Catalyzed Carbonylative Suzuki Coupling of Benzyl Halides with Potassium Aryltrifluoroborates in Aqueous Media
Author(s) -
Wu XiaoFeng,
Neumann Helfried,
Beller Matthias
Publication year - 2011
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201000804
Subject(s) - chemistry , halide , palladium , catalysis , carbonylation , aqueous medium , yield (engineering) , potassium , organic chemistry , aqueous solution , medicinal chemistry , carbon monoxide , materials science , metallurgy
A general palladium‐catalyzed carbonylative cross‐coupling reaction of benzyl chlorides with potassium aryltrifluoroborates in water has been developed. Applying this improved methodology 16 different 1,2‐diarylethanones have been synthesized in 40–89% yield.
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