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Synthesis of Azomethines from α‐Oxocarboxylates, Amines and Aryl Bromides via One‐Pot Three‐Component Decarboxylative Coupling
Author(s) -
Rudolphi Felix,
Song Bingrui,
Gooßen Lukas J.
Publication year - 2011
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201000798
Subject(s) - chemistry , bimetallic strip , aryl , halide , catalysis , coupling reaction , copper , coupling (piping) , palladium , decarboxylation , component (thermodynamics) , organic chemistry , potassium , polymer chemistry , combinatorial chemistry , alkyl , mechanical engineering , physics , engineering , thermodynamics
A bimetallic palladium/copper catalyst system allows the highly modular synthesis of azomethines via the decarboxylative coupling of aryl halides and α‐iminocarboxylates, generated in situ from potassium α‐oxocarboxylates and primary amines. The reaction proceeds already at 100 °C, a new record for redox‐neutral decarboxylative cross‐coupling reactions.