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Calcium‐Catalyzed Direct Amination of π‐Activated Alcohols
Author(s) -
Haubenreisser Stefan,
Niggemann Meike
Publication year - 2011
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201000768
Subject(s) - chemistry , amination , nucleophile , catalysis , reactivity (psychology) , organic chemistry , calcium , alkylation , allylic rearrangement , nitrogen , medicine , alternative medicine , pathology
A calcium‐catalyzed direct amination of π‐activated alcohols with different nitrogen nucleophiles under very mild reaction conditions is presented. The high reactivity of the calcium catalyst allows for an efficient conversion of secondary and tertiary benzylic and allylic as well as tertiary propargylic alcohols. Nitrogen nucleophiles such as carbamates, tosylamides and anilines are readily alkylated at room temperature.