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Base‐Mediated Tandem Reaction Consisting of an Acyl Shift Strategy Leading to 4,5‐Disubstiuted Furan‐2(5 H )‐ones
Author(s) -
Lei Yong,
Wang ZhiQiang,
Xie YeXiang,
Yu ShangCi,
Tang BoXiao,
Li JinHeng
Publication year - 2011
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201000762
Subject(s) - chemistry , decarbonylation , tandem , furan , base (topology) , cascade reaction , stereochemistry , catalysis , organic chemistry , mathematical analysis , materials science , mathematics , composite material
The first example of the synthesis of 4,5‐disubstiuted furan‐2(5 H )‐ones by base‐mediated tandem acyl shift/cyclization/decarbonylation reactions of aroylmethyl 2‐alkynoates has been developed. This new and inexpensive tandem route allows both a CO bond and a C sp 3 C sp 2 bond forming in one step involving an unprecedented acyl rearrangement process.