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Efficient Synthesis of 9‐Tosylaminofluorene Derivatives by Boron Trifluoride Etherate‐Catalyzed Aza‐Friedel–Crafts Reaction of in situ Generated N ‐Tosylbenzaldimines
Author(s) -
Yu Xufen,
Lu Xiyan
Publication year - 2011
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201000732
Subject(s) - boron trifluoride , chemistry , friedel–crafts reaction , catalysis , anthracene , substrate (aquarium) , boron , one pot synthesis , in situ , medicinal chemistry , organic chemistry , combinatorial chemistry , oceanography , geology
An efficient and expeditious boron trifluoride etherate (BF 3 ⋅Et 2 O) catalyzed one‐pot reaction for the synthesis of N ‐tosyl‐9‐aminofluorenes and anthracene derivatives from in situ generated N ‐tosylbenzaldimines via an aza‐Friedal–Crafts reaction has been developed. The catalytic reaction shows high substrate tolerance with excellent yields.