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Ligand‐Free Copper‐Catalyzed Amination of Heteroaryl Halides with Alkyl‐ and Arylamines
Author(s) -
Liu ZhenJiang,
Vors JeanPierre,
Gesing Ernst R. F.,
Bolm Carsten
Publication year - 2010
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201000708
Subject(s) - chemistry , amination , halide , alkyl , aminopyridines , catalysis , ligand (biochemistry) , copper , yield (engineering) , organic chemistry , combinatorial chemistry , medicinal chemistry , receptor , biochemistry , materials science , metallurgy
N ‐Heteroarylations of alkyl‐ and arylamines with various heteroaryl halides have been achieved by ligand‐free copper‐catalyzed cross‐couplings affording aminopyridines and aminopyrimidines in moderate to high yields (up to 99% yield).