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Palladium‐Catalyzed Synthesis of 2‐Fluoroalkyl‐3‐methylene‐3 H ‐indoles Through a Domino Carbopalladation/CH Activation Process
Author(s) -
Chen Zixian,
Zhu Jiangtao,
Xie Haibo,
Li Shan,
Wu Yongming,
Gong Yuefa
Publication year - 2011
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201000689
Subject(s) - chemistry , methylene , palladium , catalysis , domino , cascade reaction , combinatorial chemistry , cascade , medicinal chemistry , organic chemistry , chromatography
A novel palladium‐catalyzed synthesis of substituted 3‐methylene‐3 H ‐indoles from readily accessible alkynylimines has been developed. A wide variety of 2‐fluoroalkyl‐3‐methylene‐3 H ‐indoles were synthesized in moderate to good yields through this cascade carbopalladation/CH activation process. This reaction can also be expanded to non‐fluorinated substrates.