Palladium‐Catalyzed Synthesis of 2‐Fluoroalkyl‐3‐methylene‐3 H ‐indoles Through a Domino Carbopalladation/CH Activation Process | Zendy

Chen Zixian | Zendy; Zhu Jiangtao | Zendy; Xie Haibo | Zendy; Li Shan | Zendy; Wu Yongming | Zendy; Gong Yuefa | Zendy

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Palladium‐Catalyzed Synthesis of 2‐Fluoroalkyl‐3‐methylene‐3 H ‐indoles Through a Domino Carbopalladation/CH Activation Process

Author(s) -

Chen Zixian,

Zhu Jiangtao,

Xie Haibo,

Li Shan,

Wu Yongming,

Gong Yuefa

Publication year - 2011

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201000689

Subject(s) - chemistry , methylene , palladium , catalysis , domino , cascade reaction , combinatorial chemistry , cascade , medicinal chemistry , organic chemistry , chromatography

A novel palladium‐catalyzed synthesis of substituted 3‐methylene‐3 H ‐indoles from readily accessible alkynylimines has been developed. A wide variety of 2‐fluoroalkyl‐3‐methylene‐3 H ‐indoles were synthesized in moderate to good yields through this cascade carbopalladation/CH activation process. This reaction can also be expanded to non‐fluorinated substrates.

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