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Intermolecular Hydrogen Abstraction Reaction between Nitrogen Radicals in Purine Rings and Alkyl Ethers: A Highly Selective Method for the Synthesis of N‐9 Alkylated Purine Nucleoside Derivatives
Author(s) -
Guo HaiMing,
Xia Chao,
Niu HongYing,
Zhang XiaoTing,
Kong SiNan,
Wang DongChao,
Qu GuiRong
Publication year - 2011
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201000682
Subject(s) - chemistry , purine , alkylation , intermolecular force , hydrogen atom abstraction , radical , alkyl , nucleoside , organic chemistry , combinatorial chemistry , photochemistry , stereochemistry , molecule , catalysis , enzyme
A highly selective method for the synthesis of N‐9 alkylated purine nucleoside derivatives via an intermolecular hydrogen abstraction reaction between nitrogen radicals in purine rings and alkyl ethers was developed. Novel purine nucleoside derivatives were obtained with good to high yields in the presence of (diacetoxyiodo)benzene (DIB) and iodine in one‐step reaction.