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Proline‐Derived Aminotriazole Ligands: Preparation and Use in the Ruthenium‐Catalyzed Asymmetric Transfer Hydrogenation
Author(s) -
Cambeiro Xacobe C.,
Pericàs Miquel A.
Publication year - 2011
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201000678
Subject(s) - chemistry , transfer hydrogenation , ruthenium , proline , catalysis , asymmetric hydrogenation , hydroxyproline , combinatorial chemistry , noyori asymmetric hydrogenation , enantioselective synthesis , organic chemistry , amino acid , biochemistry
The preparation of 2‐triazolyl‐ and 2‐triazolylmethylpyrrolidines from L ‐proline and L ‐ trans ‐4‐hydroxyproline is described, along with their evaluation as chiral ligands in ruthenium‐catalyzed asymmetric transfer hydrogenation. Modular evolution of the ligands by introduction of remote substituents is also presented, showing a surprisingly important effect on the performance of the ligands.