Proline‐Derived Aminotriazole Ligands: Preparation and Use in the Ruthenium‐Catalyzed Asymmetric Transfer Hydrogenation | Zendy

Cambeiro Xacobe C. | Zendy; Pericàs Miquel A. | Zendy

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Proline‐Derived Aminotriazole Ligands: Preparation and Use in the Ruthenium‐Catalyzed Asymmetric Transfer Hydrogenation

Author(s) -

Cambeiro Xacobe C.,

Pericàs Miquel A.

Publication year - 2011

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201000678

Subject(s) - chemistry , transfer hydrogenation , ruthenium , proline , catalysis , asymmetric hydrogenation , hydroxyproline , combinatorial chemistry , noyori asymmetric hydrogenation , enantioselective synthesis , organic chemistry , amino acid , biochemistry

The preparation of 2‐triazolyl‐ and 2‐triazolylmethylpyrrolidines from L ‐proline and L ‐ trans ‐4‐hydroxyproline is described, along with their evaluation as chiral ligands in ruthenium‐catalyzed asymmetric transfer hydrogenation. Modular evolution of the ligands by introduction of remote substituents is also presented, showing a surprisingly important effect on the performance of the ligands.

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