Organocatalytic Multiple Cascade Reactions: A New Strategy for the Construction of Enantioenriched Tetrahydrocarbazoles | Zendy

Cao YiJu | Zendy; Cheng HongGang | Zendy; Lu LiangQiu | Zendy; Zhang JiJi | Zendy; Cheng Ying | Zendy; Chen JiaRong | Zendy; Xiao WenJing | Zendy

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Organocatalytic Multiple Cascade Reactions: A New Strategy for the Construction of Enantioenriched Tetrahydrocarbazoles

Author(s) -

Cao YiJu,

Cheng HongGang,

Lu LiangQiu,

Zhang JiJi,

Cheng Ying,

Chen JiaRong,

Xiao WenJing

Publication year - 2011

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201000610

Subject(s) - chemistry , cascade , aromatization , alkylation , friedel–crafts reaction , yield (engineering) , organocatalysis , combinatorial chemistry , cascade reaction , organic chemistry , catalysis , enantioselective synthesis , materials science , chromatography , metallurgy

A novel cascade Friedel–Crafts alkylation/Michael addition/aromatization reaction of 2‐vinylindoles with α,β‐unsaturated aldehydes has been developed for the construction of functionalized tetrahydrocarbazoles. The products were obtained in up to 97% yield and with excellent stereoselectivities ( ee up to>99%, dr up to>99:1).

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