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Direct Aldol–Reduction Process using Difluoromethyl Aryl Ketones and Aryl Aldehydes in the Presence of Potassium tert ‐Butoxide: One‐Pot Efficient Stereoselective Synthesis of Symmetrical and Unsymmetrical anti ‐2,2‐Difluoropropane‐1,3‐diols
Author(s) -
Xu Wei,
Médebielle Maurice,
Bellance MarieHélène,
Dolbier William R.
Publication year - 2010
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201000548
Subject(s) - chemistry , aryl , stereoselectivity , deprotonation , aldol reaction , anhydrous , organic chemistry , potassium , dimethylformamide , potassium fluoride , medicinal chemistry , solvent , catalysis , fluoride , alkyl , ion , inorganic chemistry
The potassium tert ‐butoxide.mediated deprotonation of two difluoromethyl aryl ketones in the presence of aryl aldehydes in anhydrous dimethylformamide (DMF), provides an efficient and stereoselective synthesis of anti ‐2,2‐difluoropropane‐1,3‐diols. Both symmetrical and unsymmetrical diols could be prepared in moderate to good yields from readily available starting materials.