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First Highly Enantioselective Synthesis of Benzodiazepinones by Catalytic Hydrogenation
Author(s) -
Rueping Magnus,
Merino Estíbaliz,
Koenigs René M.
Publication year - 2010
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201000547
Subject(s) - enantioselective synthesis , chemistry , catalysis , functional group , combinatorial chemistry , organic chemistry , asymmetric hydrogenation , polymer
The first catalytic enantioselective synthesis of benzodiazepinones employing an efficient hydrogenation protocol has been developed. The corresponding products are obtained in good yields, with excellent enantioselectivities and broad functional group tolerance. In addition, a one‐pot procedure involving in situ generation of benzodiazepin‐2‐ones followed by asymmetric reduction is presented.