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Combination Catalysis in Enantioselective Trifluoromethylation
Author(s) -
Zheng Yan,
Ma JunAn
Publication year - 2010
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201000545
Subject(s) - trifluoromethylation , enantioselective synthesis , chemistry , nucleophile , cinchona , electrophile , cinchona alkaloids , catalysis , organic chemistry , organocatalysis , combinatorial chemistry , trifluoromethyl , alkyl
The application of combination catalysis in enantioselective trifluoromethylation reactions is illustrated. Four ground‐breaking studies have described the efficient catalytic enantioselective nucleophilic trifluoromethylation of ketones and azomethine imines in the presence of the combination of a Cinchona alkaloid‐derived ammonium salt and different nucleophilic initiators, whereas the highly enantioselective electrophilic and radical trifluoromethylation of aldehydes could be achieved via the combination of chiral organocatalysts and metal salts.