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Efficient and General Continuous‐Flow Hydroarylation and Hydroalkylation of Styrenes
Author(s) -
Rueping Magnus,
Bootwicha Teerawut,
Sugiono Erli
Publication year - 2010
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201000538
Subject(s) - chemistry , nucleophile , catalysis , continuous flow , flow (mathematics) , simple (philosophy) , organic chemistry , combinatorial chemistry , biochemical engineering , mathematics , philosophy , geometry , epistemology , engineering
A simple and efficient continuous‐flow hydroarylation of arenes and heteroarenes using various styrenes in conjunction with a heterogeneous catalyst has been developed. Additionally, this method has been successfully extended to the hydroalkylation of styrenes by employing 1,3‐dicarbonyl compounds as the nucleophile. Multigram quantities of diarylmethanes have been prepared using this new flow method.