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One‐Pot Synthesis of Spirooxindole Derivatives Catalyzed by Lipase in the Presence of Water
Author(s) -
Chai SheJie,
Lai YiFeng,
Xu JiangCheng,
Zheng Hui,
Zhu Qing,
Zhang PengFei
Publication year - 2011
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201000523
Subject(s) - chemistry , lipase , catalysis , yield (engineering) , one pot synthesis , condensation , combinatorial chemistry , organic chemistry , enzyme , materials science , physics , metallurgy , thermodynamics
A facile one‐pot synthesis route to spirooxindole derivatives was developed by combining the three types of catalytic activities of lipase from porcine pancreas (PPL) in the presence of water, i.e., the Knoevengel condensation, Michael addition and cyclization. PPL showed excellent catalytic activity and have a good adaptability to different substrates in the reaction. All the reactions go smoothly and provide spirooxindole derivatives with high yield under the mild conditions. This lipase‐catalyzed multistep conversion method has provided a new strategy to synthesize spirooxindole derivatives and expanded the application of biocatalysts.