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Combining Designer Cells and Click Chemistry for a One‐Pot Four‐Step Preparation of Enantiopure β‐Hydroxytriazoles
Author(s) -
Szymanski Wiktor,
Postema Christiaan P.,
Tarabiono Chiara,
Berthiol Florian,
CampbellVerduyn Lachlan,
de Wildeman Stefaan,
de Vries Johannes G.,
Feringa Ben L.,
Janssen Dick B.
Publication year - 2010
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201000502
Subject(s) - enantiopure drug , chemistry , click chemistry , enantiomer , combinatorial chemistry , catalysis , enantiomeric excess , sequence (biology) , organic chemistry , chromatography , enantioselective synthesis , biochemistry
The multistep catalytic process using designer cells, either added as freshly prepared suspensions or as stable lyophilized powder, and click reaction can be performed in one pot. The sequence of four reactions allows the production of both enantiomers of β‐hydroxytriazoles with high enantiomeric excess.