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Iridium‐Catalyzed Asymmetric Hydrogenation of Quinoline Derivatives with C 3 *‐TunePhos
Author(s) -
Gou FaRong,
Li Wei,
Zhang Xumu,
Liang YongMin
Publication year - 2010
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201000485
Subject(s) - iridium , quinoline , chemistry , enantioselective synthesis , asymmetric hydrogenation , catalysis , combinatorial chemistry , optically active , organic chemistry
A series of C 3 *‐TunePhos chiral diphosphine ligands has been successfully applied in the iridium‐catalyzed enantioselective hydrogenation of quinolines, and this methodology provided an efficient access to a variety of optically active tetrahydroquinolines with up to 93% ee . Furthermore, attempts on the asymmetric hydrogenation of quinoline N ‐oxide are also discussed.