Premium
Iridium‐Catalyzed Asymmetric Hydrogenation of Quinoline Derivatives with C 3 *‐TunePhos
Author(s) -
Gou FaRong,
Li Wei,
Zhang Xumu,
Liang YongMin
Publication year - 2010
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201000485
Subject(s) - iridium , quinoline , chemistry , enantioselective synthesis , asymmetric hydrogenation , catalysis , combinatorial chemistry , optically active , organic chemistry
A series of C 3 *‐TunePhos chiral diphosphine ligands has been successfully applied in the iridium‐catalyzed enantioselective hydrogenation of quinolines, and this methodology provided an efficient access to a variety of optically active tetrahydroquinolines with up to 93% ee . Furthermore, attempts on the asymmetric hydrogenation of quinoline N ‐oxide are also discussed.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom