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Enantioselective Organocatalytic Transfer Hydrogenation of α‐Imino Esters by Utilization of Benzothiazoline as Highly Efficient Reducing Agent
Author(s) -
Zhu Chen,
Akiyama Takahiko
Publication year - 2010
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201000328
Subject(s) - chemistry , transfer hydrogenation , enantioselective synthesis , organocatalysis , phosphoric acid , reducing agent , catalysis , organic chemistry , combinatorial chemistry , ruthenium
Abstract Benzothiazoline was employed as an efficient and versatile reducing agent for the chiral phosphoric acid‐catalyzed transfer hydrogenation of α‐imino esters. The corresponding α‐amino esters were furnished with excellent enantioselectivities. Novel and readily removable benzothiazolines bearing a hydroxy group were also investigated.