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A General and Practical Access to Chiral Quinoxalinones with Low Copper‐Catalyst Loading
Author(s) -
Tanimori Shinji,
Kashiwagi Hiroaki,
Nishimura Takeshi,
Kirihata Mitsunori
Publication year - 2010
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201000323
Subject(s) - copper , chemistry , catalysis , chloride , copper chloride , combinatorial chemistry , organic chemistry
A general, straightforward, and practical access to multi‐substituted chiral quinoxalin‐2‐ones has been achieved based on the copper(I) chloride‐dimethylethylenediamine (DMEDA) catalyst system. With the use of 1 mol% copper(I) chloride, structurally diverse quinoxalin‐2‐ones were generated with high optical purity from readily available starting materials, 2‐haloanilines and α‐amino acids, in a one‐pot manner.

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