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A Novel One‐Pot, Two‐Step Synthesis of Polycyclic Indoles via Tandem Intramolecular Hydroamidation/Palladium‐Catalyzed Annulation
Author(s) -
Liu Jianxiu,
Zhang Yongda,
Li Guisheng,
Roschangar Frank,
Farina Vittorio,
Senanayake Chris H.,
Lu Bruce Z.
Publication year - 2010
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201000288
Subject(s) - annulation , chemistry , palladium , intramolecular force , tandem , catalysis , indole test , combinatorial chemistry , stereochemistry , organic chemistry , materials science , composite material
A robust one‐pot process has been developed for the synthesis of a variety of polycyclic indole skeletons via a consecutive sequence of hydroamidation and palladium‐catalyzed annulation, from inexpensive 2‐chloroanilines bearing tethered acetylenes.