Asymmetric Synthesis of Maraviroc (UK‐427,857) | Zendy

Zhao GuiLing | Zendy; Lin Shuangzheng | Zendy; Korotvička Aleš | Zendy; Deiana Luca | Zendy; Kullberg Martin | Zendy; Córdova Armando | Zendy

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Asymmetric Synthesis of Maraviroc (UK‐427,857)

Author(s) -

Zhao GuiLing,

Lin Shuangzheng,

Korotvička Aleš,

Deiana Luca,

Kullberg Martin,

Córdova Armando

Publication year - 2010

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201000287

Subject(s) - maraviroc , chemistry , enantioselective synthesis , stereochemistry , ccr5 receptor antagonist , aldehyde , antagonist , combinatorial chemistry , receptor , organic chemistry , biochemistry , catalysis , virology , chemokine , chemokine receptor , human immunodeficiency virus (hiv) , biology

The asymmetric synthesis of Maraviroc (UK‐427,857), a chemochine receptor 5 (CCR‐5) receptor antagonist, based on an expeditious organocatalytic enantioselective assembly of the chiral β‐amino aldehyde key fragment is presented. The reactions were performed on a gram‐scale and allow for the rapid construction of new Maraviroc analogues.

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