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Asymmetric Synthesis of Maraviroc (UK‐427,857)
Author(s) -
Zhao GuiLing,
Lin Shuangzheng,
Korotvička Aleš,
Deiana Luca,
Kullberg Martin,
Córdova Armando
Publication year - 2010
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201000287
Subject(s) - maraviroc , chemistry , enantioselective synthesis , stereochemistry , ccr5 receptor antagonist , aldehyde , antagonist , combinatorial chemistry , receptor , organic chemistry , biochemistry , catalysis , virology , chemokine , chemokine receptor , human immunodeficiency virus (hiv) , biology
The asymmetric synthesis of Maraviroc (UK‐427,857), a chemochine receptor 5 (CCR‐5) receptor antagonist, based on an expeditious organocatalytic enantioselective assembly of the chiral β‐amino aldehyde key fragment is presented. The reactions were performed on a gram‐scale and allow for the rapid construction of new Maraviroc analogues.