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Microwave‐Assisted Dieckmann Reaction: Efficient One‐Step Synthesis of 2‐Aroylbenzofuran‐3‐ols
Author(s) -
Zhou ZhongZhen,
Deng YanHong,
Jiang ZhiHong,
Chen WenHua
Publication year - 2010
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201000256
Subject(s) - chemistry , compatibility (geochemistry) , microwave , combinatorial chemistry , catalysis , reaction conditions , organic chemistry , chemical engineering , computer science , telecommunications , engineering
This paper describes the first efficient one‐step synthesis of 2‐aroylbenzofuran‐3‐ols from the microwave‐assisted Dieckmann reaction of substituted methylsalicylates with 2‐bromo‐1‐aroylethanones in alkaline aprotic solvents. This method features excellent yields, short reaction time (15 min) and high functional group compatibility, making it an efficient and practical approach for the synthesis of 2‐aroylbenzofuran‐3‐ols.