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Well‐Defined Allylnickel Chloride/N‐Heterocyclic Carbene [(NHC)Ni(allyl)Cl] Complexes as Highly Active Precatalysts for CN and CS Cross‐Coupling Reactions
Author(s) -
Iglesias María José,
Prieto Auxiliadora,
Nicasio M. Carmen
Publication year - 2010
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201000223
Subject(s) - chemistry , carbene , steric effects , amination , catalysis , medicinal chemistry , chloride , polymer chemistry , organic chemistry
The room temperature Buchwald–Hartwig amination of heteroaromatic chlorides has been achieved using the sterically bulky allylnickel chloride/N‐heterocyclic carbene [(IPr)Ni(allyl)Cl] complex as a well‐defined precatalyst. Arylation of aromatic thiols, affording high yields of products under low catalyst loadings, has also been promoted with the same complex.