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Efficient Synthesis of 2‐Fluoromethylated Quinolines via Copper‐Catalyzed Alkynylation and Cyclization of Fluorinated Imidoyl Iodides
Author(s) -
Li Shan,
Yuan Yafen,
Zhu Jiangtao,
Xie Haibo,
Chen Zixian,
Wu Yongming
Publication year - 2010
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201000180
Subject(s) - chemistry , alkynylation , catalysis , iodide , aryl , copper , medicinal chemistry , combinatorial chemistry , organic chemistry , alkyl
2‐Fluoromethylated quinolines were synthesized through the reaction of N ‐aryl‐fluorinated imidoyl iodides with terminal alkynes in good yields by the catalysis of copper(I) iodide (CuI) alone.