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Single Nucleotide‐Catalyzed Biomimetic Reductive Amination
Author(s) -
Kumar Atul,
Sharma Siddharth,
Maurya Ram Awatar
Publication year - 2010
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201000178
Subject(s) - reductive amination , chemistry , nucleotide , combinatorial chemistry , amination , catalysis , enantioselective synthesis , organic chemistry , reducing agent , biochemistry , gene
We have successfully developed a single nucleotide (adenosine 5′‐diphosphate)‐catalyzed enantioselective direct reductive amination of aldehydes and ketones using a Hantzsch ester as reducing agent. The process is a simple, efficient and a real mimic of the NADH reduction approach for the synthesis of structurally diverse amines. This reaction is the first report demonstrating the ability of a single nucleotide as catalyst and one of the most genuine biomimetic reactions of organic chemistry.