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Facile Assembly of H ‐Pyrazolo[5,1‐ a ]isoquinolines via Silver Triflate‐Catalyzed One‐Pot Tandem Reaction of 2‐Alkynyl‐ benzaldehyde, Sulfonohydrazide, and Ketone or Aldehyde
Author(s) -
Yu Xingxin,
Ye Shengqing,
Wu Jie
Publication year - 2010
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201000176
Subject(s) - chemistry , aldehyde , trifluoromethanesulfonate , benzaldehyde , ketone , catalysis , tandem , selectivity , cascade reaction , organic chemistry , medicinal chemistry , combinatorial chemistry , materials science , composite material
A novel and efficient route for the generation of H ‐pyrazolo[5,1‐ a ]isoquinolines via silver triflate‐catalyzed one‐pot tandem reaction of 2‐alkynylbenzaldehyde, sulfonohydrazide, and ketone or aldehyde is described. This reaction proceeds with good functional group tolerance under mild conditions with high efficiency and excellent selectivity.