Premium
Enantioselective Carbonyl‐Ene Reactions of Trifluoropyruvate in Ionic Liquid via a Recyclable Indium(III)‐Pybox Complex
Author(s) -
Zhao Jun Feng,
Tan Boon Hong,
Zhu Ming Kui,
Tjan Teguh Budiono W.,
Loh Teck Peng
Publication year - 2010
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201000170
Subject(s) - enantioselective synthesis , chemistry , ionic liquid , indium , trifluoromethyl , catalysis , ene reaction , organic chemistry , medicinal chemistry , alkyl
Abstract A highly enantioselective carbonyl‐ene reaction of trifluoropyruvate catalyzed by a recyclable indium(III)‐pybox complex in ionic liquid afforded trifluoromethyl‐containing tertiary homoallylic alcohols with excellent yields (up to 98%) and enantioselectivities (up to 98% ee ). Notably, this catalytic system can be recycled up to seven cycles.