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Highly Enantioselective Michael Addition Reactions of 3‐Substituted Benzofuran‐2(3 H )‐ones to Chalcones Catalyzed by a Chiral Alkyl‐Substituted Thiourea
Author(s) -
Li Xin,
Xi Zhiguo,
Luo Sanzhong,
Cheng JinPei
Publication year - 2010
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201000106
Subject(s) - enantioselective synthesis , chemistry , benzofuran , thiourea , bifunctional , stereocenter , michael reaction , alkyl , catalysis , organocatalysis , organic chemistry , combinatorial chemistry , medicinal chemistry
A highly enantioselective Michael addition of 3‐substituted benzofuran‐2(3 H )‐ones to chalcones catalyzed by a chiral bifunctional thiourea was developed. Several chiral 3,3′‐substituted benzofuran‐2(3 H )‐ones derivatives, bearing adjacent quaternary‐tertiary stereocenters, were efficiently synthesized with excellent enantioselectivities.