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Copper‐Catalyzed Cross‐Dehydrogenative Coupling (CDC) of Alkynes and Benzylic CH Bonds
Author(s) -
Correia Camille A.,
Li ChaoJun
Publication year - 2010
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201000066
Subject(s) - chemistry , trifluoromethanesulfonate , catalysis , copper , medicinal chemistry , coupling reaction , coupling (piping) , polymer chemistry , combinatorial chemistry , photochemistry , organic chemistry , mechanical engineering , engineering
The activation of benzylic CH bonds and subsequent coupling with terminal alkynes in the presence of 2,3‐dichloro‐5,6‐dicyanoquinone (DDQ) and a catalytic amount of copper(I) triflate is presented. Good to moderate yields of disubstituted alkynes are obtained for this cross‐dehydrogenative coupling (CDC) reaction between a variety of aromatic alkynes and diphenylmethane derivatives.