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Base‐ and Copper‐Catalyzed Intramolecular Cyclization for the Direct Synthesis of Dihydrofurans
Author(s) -
Chen YongFei,
Wang HaiFei,
Wang Ya,
Luo YongChun,
Zhu HaiLiang,
Xu PengFei
Publication year - 2010
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201000005
Subject(s) - chemistry , trifluoroacetic acid , trifluoromethanesulfonate , dichloromethane , propynyl , catalysis , triphenylphosphine , copper , methanol , medicinal chemistry , intramolecular force , solvent , organic chemistry
A simple and convenient synthetic approach to dihydrofurans has been developed from the cyclization of 2‐propynyl‐1,3‐dicarbonyl compounds catalyzed by potassium tert ‐butoxide, copper(II) trifluoromethanesulfonate and triphenylphosphine using methanol/dichloromethane as the solvent under very mild conditions. Moreover, dihydrofurans could be easily transformed into the corresponding furans in the presence of trifluoroacetic acid.