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Copper(I)‐Catalyzed Synthesis of Novel 4‐(Trifluoromethyl)‐[1,2,3]triazolo[1,5‐ a ]quinoxalines via Cascade Reactions of N ‐( o ‐Haloaryl)alkynylimine with Sodium Azide
Author(s) -
Chen Zixian,
Zhu Jiangtao,
Xie Haibo,
Li Shan,
Wu Yongming,
Gong Yuefa
Publication year - 2010
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200900875
Subject(s) - chemistry , trifluoromethyl , sodium azide , catalysis , tandem , combinatorial chemistry , copper , azide , cascade reaction , medicinal chemistry , tricyclic , cascade , organic chemistry , alkyl , materials science , chromatography , composite material
Novel tricyclic 4‐(trifluoromethyl)‐[1,2,3]triazolo[1,5‐ a ]quinoxalines were readily prepared from N ‐( o ‐haloaryl)alkynylimines and sodium azide via copper(I)‐catalyzed tandem reactions. This synthetic strategy provides an efficient way to access a library of novel heterocyclic compounds that are of interest in drug discovery.