Copper(I)‐Catalyzed Synthesis of Novel 4‐(Trifluoromethyl)‐[1,2,3]triazolo[1,5‐ a ]quinoxalines  via  Cascade Reactions of  N ‐( o ‐Haloaryl)alkynylimine with Sodium Azide | Zendy

Chen Zixian | Zendy; Zhu Jiangtao | Zendy; Xie Haibo | Zendy; Li Shan | Zendy; Wu Yongming | Zendy; Gong Yuefa | Zendy

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Copper(I)‐Catalyzed Synthesis of Novel 4‐(Trifluoromethyl)‐[1,2,3]triazolo[1,5‐ a ]quinoxalines via Cascade Reactions of N ‐( o ‐Haloaryl)alkynylimine with Sodium Azide

Author(s) -

Chen Zixian,

Zhu Jiangtao,

Xie Haibo,

Li Shan,

Wu Yongming,

Gong Yuefa

Publication year - 2010

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.200900875

Subject(s) - chemistry , trifluoromethyl , sodium azide , catalysis , tandem , combinatorial chemistry , copper , azide , cascade reaction , medicinal chemistry , tricyclic , cascade , organic chemistry , alkyl , materials science , chromatography , composite material

Novel tricyclic 4‐(trifluoromethyl)‐[1,2,3]triazolo[1,5‐ a ]quinoxalines were readily prepared from N ‐( o ‐haloaryl)alkynylimines and sodium azide via copper(I)‐catalyzed tandem reactions. This synthetic strategy provides an efficient way to access a library of novel heterocyclic compounds that are of interest in drug discovery.

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